# Bronnen

# Bronnen voor deze website

- Nectar VWO 4, 5 en 6.
- 10voorbiologie
- http://dekennisvannu.nl/site/artikel/Wat-is-CRISPR-Cas-en-waarom-is-het-revolutionair/8016

# Literatuurlijst​

- Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. (2008). Molecular Biology of THE CELL. New York: Garland Science Taylor & Frabscis Group.
- Bain, L.J. (2014). Alzheimer´s Disease Summit. The path to 2025. The New York Academy of Sciences. http://www.nyas.org/Publications/Ebriefings/Detail.aspx?cid=e7aa2db6-e559-44c9-b50e-18f31055ca26 geraadpleegd op 21 januari 2017.
- Bird, T.D. (2008). Genetic aspects of Alzheimer disease. Genetics in medicine 10, 231-239. DOI:10.1097/GIM.0b013e31816b64dc.
- Bird, T.D. (2012). Early-Onset Familial Alzheimer Disease. GeneReviews. https://www.ncbi.nlm.nih.gov/books/NBK1236/ geraadpleegd op 11 januari 2017.
- Campbell, N.A., Reece, J.B., Urry, L.A., Cain, M.L., Wasserman, S.A., Minorsky, P.V., Jackson, R.B. (2008). Biology. Boston: Benjamin Cummings / Pearson.
- Chow, V.W., Mattson, M.P., Wong, P.C., Gleichmann, M. (2010). An Overview of APP Processing Enzymes and Products. NeuroMolecular Medicine, 12(1), 1-12. DOI: 10.1007/s12017-009-8104-z.
- Cong, L., Rann, F.A., Cox, D., Lin, S., Baretto, R., Habib, N., Hsu, P.D., Wu, X., Jiang, W., Marraffini, L.A., Zhang, F. (2013). Multiplex Genome Engeineering Using CRISPR/Cas Systems. Science, 339 (6121), 819-823. DOI: 10.1126/science.1231143
- Cyranoski, D. (2016). CRISPR gene-editing tested in a person for the first time. Nature, 539,479, DOI:10.1038/nature.2016.20988.
- Dulhaime-Ross, A. (2016). Breaktrough method means CRISPR just got a lot more relevant to human health. `The most clever CRISPR gadget to date´. The Verge. http://www.theverge.com/2016/4/20/11450262/crispr-base-editing-single-nucleotides-dna-gene-liu-harvard geraadpleegd op 18 maart 2017.
- Gentier, R.J., Leeuwen, van F.W. (2015). Misframed ubiquitin and impaired protein quality control: an early event in Alzheimer´s disease. Frontiers in Molecular Neuroscience. DOI: https://doi.org/10.3389/fnmol.2015.00047.
- Gong, C.X., Iqbal, K. (2008). Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease. Current Medicinal Chemistry, 15 (23), 2321-2328.
- Harada, B. (2015). Can Gene Editing Eliminate Alzheimer´s Disease? Physics Forums Insights. https://www.physicsforums.com/insights/can-gene-editing-eliminate-alzheimers-disease/ geraadpleegd op 19 januari 2017.
- Hendel, A., Fine, E.J., Bao, G., Porteus, M.H. (2015). Quantifying On and Off-Target Genome Editing. Trends Biotechnology, 33(2). DOI: 10.1016/j.tibtech.2014.12.001.
- Horvath, P., Barrangou, R. (2010). CRISPR/Cas, the immune system of bacteria and archaea. Science, 327 (5962), 167-70. DOI: 10.1126/science.1179555.
- Huang, H., Jiang, Z. (2009). Accumulated Amyloid-β Peptide and Hyperphosphorylated Tau Protein: Relationship and Links in Alzheimer’s Disease. Journal of Alzheimer’s Disease 16 (2009) 15–27. DOI: 10.3233/JAD-2009-0960
- Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J.A., Charpentier, E. (2012). A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science, 337(6096), 816-821. DOI: 10.1126/science.1225829.
- Jonsson, T., Atwal, J.K., Steinberg, S., Snaedal, J., Jonsson, P.V., Bjornsson, S., Stefansson, H., Sulem, P., Gudbjartsson, D., Maloney, J., Hoyte, K., Gustafson, A., Liu, Y., Lu, Y., Bhangale, T., Graham, R.R., Huttenlocher, J., Bjornsdottir, G., Andreassen, O.A., Jönsson, E.G., Palotie, A., Behrens, T.W., Magnusson, O.T., Kong, A., Thorsteinsdottir, U., Watts R.J., Stefansson, K. (2012). A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline. Nature, 488, 96–9. DOI: doi:10.1038/nature11283.
- Komor, A.C., Kim, Y.B., Packer, M.S., Zuris, J.A. & Liu, D.R. (2016). Programmable editing of target base in genomic DNA without double-stranded DNA cleavage. Nature, 533, 420-424. DOI: 10.1038/nature17946.
- Liang, P., Xu, Y., Zhang, X., Ding, C., Huang, R., Zhang, Z., Lv, J., Xie, X., Chen, Y., Li, Y., Sun, Y., Bai, Y., Songyang, Z., Ma, W., Zhou, C., Huang, J. (2015). CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein & Cell, 6 (5), 363-372. DOI: 10.1007/s13238-015-0153-5
- Miller, G. (2012). Gene Mutation Protects Against Alzheimer's. http://www.sciencemag.org/news/2012/07/gene-mutation-protects-against-alzheimers geraadpleegd op 21 januari 2017.
- Moreno, A.M., Mali, P. (2017). Therapeutic genome engeneering via CRISPR-Cas systems. WIREs Systems biology and Medicine, 1380. DOI: 10.1002/wsbm.1380.
- O´Brien, R.J., Wong, P.C. (2011). Amyloid Precursor Protein Processing and Alzheimer´s Disease. Annual Review of Neuroscience, 34, 185-204. DOI: 10.1146/annurev-neuro-061010-113613
- Paquet, D., Kwart, D., Chen, A., Sproul, A., Jacob, S., Teo, S., Olsen, K.M., Gregg, A., Noggle, S., Tessier-Lavigne, M. (2016). Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9. Nature, 533, 125–129. DOI:10.1038/nature17664.
- Poudel, B. (2015). Sustainable Agriculture. What is CRISPR Cas9 system? https://agristudentbikash.wordpress.com/2015/09/10/what-is-crispr-cas9-system/ geraadpleegd op 21 januari 2017.
- Reitz, C., Mayeux, R. (2014). Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers. Biochemical Pharmacology, 88 (4), 640-651. DOI: http://dx.doi.org/10.1016/j.bcp.2013.12.024
- Sander, J.D., Joung, J.K. (2014). CRISPR-Cas systems for editing, regulating and targeting genomes. Nature Biotechnology 32, 347–355. DOI: 10.1038/nbt.2842.
- Senís, E., Fatouros, C., Große, S., Wiedtke, E., Niopek, D., Mueller, A.K., Börner, K., Grimm, D. (2014). CRISPR/Cas9-mediated genome engineering: an adeno-associated viral (AAV) vector toolbox. Biotechnology Journal, 9(11):1402-12. DOI: 10.1002/biot.201400046. Epub 2014 Oct 6.
- Shugart, J. (z.d.). Neuroscientists Probe CRISPR Transgenics and Treatment Paradigms. Biomedical Research Forum, LLC. http://www.alzforum.org/news/research-news/neuroscientists-probe-crispr-transgenics-and-treatment-paradigms geraadpleegd op 24 april 2017.
- The Doudna Lab. (2012). CRISPR systems in prokaryotic immunity. http://rna.berkeley.edu/crispr.html geraadpleegd op 18 januari 2017.
- Tschaharganeh, D.F., Lowe, S.W., Garippa, R.J., Livshits, G. (2016). Using CRISPR/Cas to study gene function and model disease in vivo. The Febs Journal, 283(17), 3194-3203. DOI: 10.1111/febs.13750.
- Ullah, N., Khan, N.M., Ullah, W. (2015). Alzheimer’s disease, Epidemiology, causes, diagnosis and novel treatments: A review. International Journal of Basic Medical Sciences and Pharmacy, 5(2), 2049-4963.
- U.S. National Library of Medicine (2017). APP Gene. Amyloid Precursor Protein. Genetic home reference. https://ghr.nlm.nih.gov/gene/APP#conditions geraadpleegd op 18 januari 2018.
- Weggen, S., Beher, D. (2012). Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease. A lzheimer's Research & Therapy, 4(9). DOI: 10.1186/alzrt107.